GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

By Agnieszka Gambus, Richard C. Jones, Alberto Sanchez-Diaz, Masato T. Kanemaki, F. V. Deursen, R. Edmondson, K. Labib. Nature Cell Biology, 2006

814 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a2a5a18e4161f2bde11c91137e8f387481b9771b

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Citations in the corpus

• Chromatin challenges during DNA replication and repair. (2007, neutral): “Importantly, FACT was recently identified in complex with MCM proteins in yeast and human cells (Gambus et al., 2006; Tan et al., 2006).”
• Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing (2009, background): “The purified replisome progression complex (RPC), a protein assemblage containing the CMG complex as well as other replisome components, contains just a single copy of Mcm4 (and presumably the other Mcm2–7 subunits) (Gambus et al., 2006).”
• Chromatin replication and epigenome maintenance (2012, background): “, which upon initiation splits into two single hexamers that progress in opposite direction”
• Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication (2007, background): “The GINS complex in yeast interacts with Ctf4 (Gambus et al. 2006).”
• Cohesin: its roles and mechanisms. (2009, background): “, DNA polymerase α, Mcm and GINS complexes, Cdc45, Mrc1, Tof1, and Csm3) (33), and a complex formed between the Tof1 and Csm3 proteins that associates with replication forks and regulates their response to being stalled (132, 207).”
• Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS proteins (2010, background): “Cdc45-MCM2-7-GINS (CMG) complex members also copurified from S. cerevisiae lysates (Gambus et al., 2006) and associated with the replication fork in Xenopus laevis egg extracts, when the DNA helicase activity was uncoupled from active DNA polymerase (Pacek et al., 2006).”
• CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. (2010, background): “Recent studies identified the complex comprising Cdc45, Mcm, and GINS (CMG complex) from various organisms (Gambus et al. 2006; Moyer et al. 2006; Pacek et al. 2006).”
• Maintaining genome stability at the replication fork (2010, background): “The GINS complex is also important for the progression of RFs as it maintains the association between MCM and Cdc45 within the replisom”
• DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation (2023, background): “Howe v er, the human and Xenopus TopBP1 homologues are much larger proteins, containing eight BRCT domains (1-8), with an additional N-terminal BRCT domain identified in human TopBP1, named BRCT0 ( 51 ).”