Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.

By Jun‐liang Fu, Dongping Xu, Zhen-wen Liu, M. Shi, P. Zhao, B. Fu, Zheng Zhang, Hui-ying Yang, Hui Zhang, Chun-Bao Zhou and 6 more. Gastroenterology, 2007

894 citations recorded by the source corpus.

Subfields: Hepatology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1c2ec31496fb4710cb58862ab245622afc6098bf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. Natascha Roehlen
2. E. Crouchet
3. T. Baumert
4. B. Sangro

In Immunology

1. Guido Kroemer
2. L. Galluzzi
3. L. Zitvogel
4. W. Zou
5. Ilona Kryczek
6. T. Welling
7. C. Sautès-Fridman
8. Sandra Hervás-Stubbs

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. L. Zitvogel
4. T. Welling
5. C. Sautès-Fridman
6. I. Melero
7. W. Zou
8. Lieping Chen

Citations in the corpus

• The secret ally: immunostimulation by anticancer drugs (2012, background): “High levels of tumour-infiltrating FOXP3 + T reg cells negatively affect prognosis in several other neoplasms, including RCC as well as hepatocellula”
• Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells (2014, background): “regulatory cells, and suppressive tumor–associated macrophages (TAMs) all balance tumor immunity in HCC patients.(10,13,14) We and others have shown TAMs in HCC to be particularly important to this balance of immune response and overall prognosis.”
• Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression (2011, background): “It has been reported that in both experimental murine models and human patients with HCC, the frequency of CD4+ Foxp3+ Tregs was increased (36).”
• Advances in immunotherapy for hepatocellular carcinoma (2021, background): “I.M. receives funding from MINECO SAF2014-52361-R and SAF 2017- 83267-C2-1R; Worldwide Cancer Research Grant (15-1146); the Asociacion Española Contra el Cancer (AECC) Foundation under grant GCB15152947MELE; and the European Union’s Horizon 2020 Program (grant agreement no. 635122 PROCROP).”
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “Similarly, an increase of the Treg population was observed in patients with advanced fibrosis, which may promote fibrosis through secretion of IL8 [107,108].”
• Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “It was confirmed in other solid tumors, such as pancreatic ductal adenocarcinoma (Hiraoka et al., 2006b) and hepatocarcinoma (Fu et al., 2007).”