The telomere syndromes

By M. Armanios, Elizabeth H Blackburn. Nature reviews genetics, 2012

968 citations recorded by the source corpus.

There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the short telomere defect. Here we review the manifestations and unique genetics of telomere syndromes. We also discuss their underlying molecular mechanisms and significance for understanding common age-related disease processes.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/1b3800c6eca9a74d30da0468ba7db77aaf1e9432

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In Molecular Biology

1. Linda Partridge
2. Manuel Serrano
3. Guido Kroemer
4. C. López‐Otín
5. M. Blasco
6. L. Galluzzi
7. Douglas R. Green
8. Beth Levine

In Physiology

1. Manuel Serrano
2. Guido Kroemer
3. Linda Partridge
4. M. Blasco
5. C. López‐Otín
6. Jesús Gil
7. J. Campisi

Citations in the corpus

• The hallmarks of aging. (2013, background): “Telomerase deficiency in humans is associated with premature development of diseases, such as pulmonary fibrosis, dyskeratosis congenita, and aplastic anemia, which involve the loss of the regenerative capacity of different tissues (Armanios and Blackburn, 2012).”