Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
By E. Chesler, Lu Lu, S. Shou, Yanhua Qu, Jing Gu, Jintao Wang, H. Hsu, J. Mountz, Nicole E. Baldwin, M. Langston and 3 more. Nature Genetics, 2005
744 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/1ae155fbd0c4614d9f9dd9b3b57ac4d3aad7bdc6
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In Genetics
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In Molecular Biology
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Citations in the corpus
- Estimating the number of true null hypotheses from a histogram of p values (2006, methodology): “…(see, e.g., Jansen and Nap 2001; Brem, Yvert, Clinton, and Kruglyak 2002; Yvert et al. 2003; Schadt et al. 2003 a,b; Pomp, Allan, and Wesolowski 2004; Hubner et al. 2005; Bystrykh et al. 2005; Chesler et al. 2005; DeCook, Lall, Nettleton, and Howell 2006) can result in millions of tests.”
- Autism‐like behavioral phenotypes in BTBR T+tf/J mice (2008, background): “2007), Furthermore, the relatively rapid SNP strategy, although still in its infancy, appears promising for dissecting genetic polymorphisms related to complex behavioral traits in inbred strains of mice (Chesler et al. 2005).”
- Genome-wide genetic association of complex traits in heterogeneous stock mice (2006, background): “Integration of expression, sequence and other functional data with mapping information from inbred strains has been shown to aid QTL identificatio”
- An integrative genomics approach to infer causal associations between gene expression and disease (2005, background): “The chromosome 6 and chromosome 19 linkage regions are hot-spot regions for eQTL activity and are enriched for pathways underlying metabolic trait”
- Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement (2006, methodology): “A conceptual approach similar to ours has been taken in a study of polygenic gene expression networks underlying the nervous system in recombinant inbred mic”