Lactate in the brain: from metabolic end-product to signalling molecule
By Pierre J. Magistretti, Igor Allaman. Nature Reviews Neuroscience, 2018
1,082 citations recorded by the source corpus.
Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/1adbd144fde8ee562f1b063b48afcc9ef2df47bb
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Citations in the corpus
- Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity (2020, background): “In heathy CNS tissue, astrocytes maintain homeostasis of extracellular fluids, ions and transmitters [2], provide glucose metabolites as energy substrates to neurons [3], modulate local blood flow [4], help regulate drainage of interstitial fluid [5], play essential roles in synapse development and ”
- Astrocyte crosstalk in CNS inflammation (2020, background): “Under healthy conditions, lactate provided by astrocytes supports the metabolic needs of neurons (Magistretti and Allaman, 2018).”
- Episodic memory in aspects of brain information transfer by resting-state network topology (2021, background): “Notably, 550 activation of brain regions has been shown to reflect the metabolic level of neurons 551 (Magistretti and Allaman 2018).”