Faculty Opinions recommendation of A scavenger function for a Drosophila peptidoglycan recognition protein.

By M. Kanost. 2003

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The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections (2007, background): “Family members share a common PGRP domain, which is evolutionarily related to the bacteriophage type II amidases, and some members have retained this enzymatic activity (these are referred to as catalytic PGRPs”
The host defense of Drosophila melanogaster. (2007, background): “PGRP-SA encodes a secreted PGRP, which is present in the hemolymph and acts upstream of Toll in the recognition of Lys-type PGN of Gram-positive bacteria (Figure 4b).”
Insect Immunity: An Evolutionary Ecology Perspective (2005, background): “, 2002b), and (4) some peptidoglycan-recognition proteins seem to function to remove, or ‘clean up’, excess peptidoglycans in the haemocoel (Mellroth et al., 2003).”
The immune response of Drosophila (2003, background): “Sequence changes in these domains indicate that some of the PGRPs have lost their amidase function and serve essentially for recognition, whereas others, such as PGRP-SC1, have retained their enzymatic activit”
Insect immunity and its signalling: an overview (2010, background): “In addition, some PGRPs lack a critical cysteine required for the active site, and are therefore thought to function only as recognition proteins without enzymic activity (Mellroth et al., 2003).”