Activation of integrin function by nanopatterned adhesive interfaces.

By M. Arnold, E. A. Cavalcanti‐Adam, R. Glass, J. Blümmel, W. Eck, M. Kantlehner, Horst Kessler, Joachim Pius Spatz. ChemPhysChem, 2004

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Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “Using 8-nm gold particles coated with Arg-Gly-Asp (RGD) peptides that permit the binding of only a single integrin, Arnold and colleagues determined the minimum ligand spacing required for integrin-clustering-induced signaling to occur (Arnold et al., 2004).”
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. (2007, methodology): “Based on previous studies ( 34 ) and this work, it appears that there is a critical ligand (RGD) density (interligand spacing of ,70 nm) that is essential for the formation of stable integrin-mediated adhesions.”
Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “Nanopatterning methods have led to determine the maximum distance of 60 nm between integrin molecules – a distance that still allows intracellular recruitment of actin filaments and signalling molecules (Arnold et al., 2004).”