The dsRNA protein kinase PKR: virus and cell control.
By María García, E. Meurs, M. Esteban. Biochimie, 2007
665 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/186cf1aea048b510088919fb75cb61ca5f2459bb
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In Immunology
In Molecular Biology
- S. S. Cao
- Afshin Samali
- A. Gorman
- Karolina Pakos-Zebrucka
- V. Hornung
- P. Murphy
- Izabela Koryga
- Charles M. Rice
Citations in the corpus
- The eIF2α kinases: their structures and functions (2013, neutral): “Activation of PKR leads to apoptosis [58], a process that is dependent on phosphorylation of eIF2α [180], and has also been linked with NF-κB signaling [60].”
- RNA‐binding proteins and post‐transcriptional gene regulation (2008, neutral): “target RNAs, while PKR incorporates a kinase domain [31,32].”
- The integrated stress response (2016, positive): “Additionally, both PERK and GCN2 become activated during nucleofection [68] and together with PKR can regulate host response to viral infection [8,69,70].”
- The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, background): “Activated PKR phosphorylates cellular proteins, including the translation initiation factor eIF-2, resulting in arrest of translation of both cellular and viral mRNAs (75).”
- MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Activation of the PKR pathway inhibits general protein synthesis throughout the cell and induces the production of interferons, which mediate anti-proliferative and proapoptotic activity [133-135].”
- Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, background): “PKR can be activated by ER stress and multiple inflammatory stimuli (56).”
- ATP-dependent effector-like functions of RIG-I like receptors (2015, methodology): “Viral proteins, such as NS1 and E3L, are known to suppress PKR by sequestering dsRNA (Garcı́a et al., 2007), although dsRNA-independent mechanisms have also been proposed (Li et al.”