Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

By Samar I. Itani, N. Ruderman, Frank A. Schmieder, G. Boden. 2002

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The underappreciated role of muscle in health and disease. (2006, background): “Increased triacylglycerol deposition in muscle has been interpreted to be an indicator of dysfunctional muscle lipid metabolism that is likely related to insulin resistance by mechanisms independent of total body fat mass (40).”
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. (2007, background): “Thus, some scientists have argued that it either is unimportant in lipid-induced insulin resistance or, alternatively, plays only a minor role in the regulation of glucose homeostasis following nutrient oversupply (Itani et al., 2002; Yu et al., 2002).”
Pathogenesis of Insulin Resistance in Skeletal Muscle (2010, background): “[66] S.”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “For example, various abnormalities of lipid metabolism have been described which can also impair insulin signaling (Itani et al., 2002; Savage et al., 2007).”