The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

By Peter Walter, D. Ron. Science, 2011

5,694 citations recorded by the source corpus.

Subfields: Biotechnology, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/17d17fd8b90d2a9afdc877901090c9b3ab2afa37

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Citations in the corpus

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “These molecules are downstream effectors of the major pathways of the ER stress response (72, 73).”
Abiotic stress signaling and responses in plants (2016, background): “, the equilibrium between protein-folding demands and folding capacity, and are known as the unfolded protein response (UPR), a conserved stress response in eukaryotes (Walter and Ron, 2011).”
Endoplasmic reticulum stress sensing in the unfolded protein response. (2013, background): “Thus, the PERK branch first mediates a prosurvival response, which switches into a proapoptotic response on prolonged ER stress (Walter and Ron 2011).”
Using deep learning to model the hierarchical structure and function of a cell (2018, background): “These subsystems encompassed functions of PMT1 or IRE1 in the endoplasmic reticulum unfolded protein response (ER-UPR) 20,21 , cell wall organization and integrity 22,23 , and many other processes ( Fig.”
The Unfolded Protein Response and Cell Fate Control. (2017, positive): “PERK is a type I transmembrane kinase that under ER stress conditions oligomerizes and trans-autophosphorylates, inhibiting general protein translation through the phosphorylation of eukaryotic translation initiator factor-2 (eIF2a) at serine 51 (Walter and Ron, 2011).”
ER stress: Autophagy induction, inhibition and selection (2015, background): “Transcription factor ATF4 translocates to the nucleus and activates a set of UPR target genes involved in amino acid metabolism, antioxidant responses, autophagy, and apoptosis.(133,232) Induction.”
Pharmacological brake-release of mRNA translation enhances cognitive memory (2013, background): “Transcriptional targets of the UPR include the ER protein folding machinery, the ER-associated degradation machinery, and many other components functioning in the secretory pathway (Walter and Ron, 2011).”
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress (2020, background): “The endoplasmic reticulum (ER) is a highly dynamic heterogeneous cellular network that mediates folding and maturation of ~40% of the proteome (Walter and Ron, 2011; Sun and Brodsky, 2019).”
The endoplasmic reticulum: structure, function and response to cellular signaling (2015, background): “The UPR consists of three parallel branches that are activated upon stress and include inositol requiring enzyme 1 (IRE1) by nonconventional splicing, double-stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK) through translational control by phosphorylating eIF2a, and activating trans”
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome (2012, background): “…mRNA in mouse and human primary islets treated with (E) Expression of TXNIP protein in INS-1 832/13 cells treated with thapsigargin (TG treated with tunicamycin (TM, 5 mg/ml) for 24 hr. n = 3; values are shown as mean ± SD. Cel transcriptional and posttranscriptional levels (Walter and Ron, 2011).”