IMGT, the international ImMunoGeneTics information system®

By Marie-Paule Lefranc, Véronique Giudicelli, Q. Kaas, E. Duprat, Joumana Jabado-Michaloud, Dominique Scaviner, Chantal Ginestoux, Oliver Clément, D. Chaume, G. Lefranc. Nucleic Acids Res., 2004

885 citations recorded by the source corpus.

The international ImMunoGeneTics information system® (IMGT) (http://imgt.cines.fr), created in 1989, by the Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier II and CNRS) at Montpellier, France, is a high-quality integrated knowledge resource specializing in the immunoglobulins (IGs), T cell receptors (TRs), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune systems (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT includes several sequence databases (IMGT/LIGM-DB, IMGT/PRIMER-DB, IMGT/PROTEIN-DB and IMGT/MHC-DB), one genome database (IMGT/GENE-DB) and one three-dimensional (3D) structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages (IMGT Marie-Paule page), and interactive tools. IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on the IMGT-ONTOLOGY concepts. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in normal physiological and pathological situations. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow up of residual diseases) and therapeutical approaches (graft, immunotherapy and vaccinology). IMGT is freely available at http://imgt.cines.fr.

View Paper: https://www.semanticscholar.org/paper/17befabc0ca463b0647ef2a759f4aac8144a54b6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

IMGT®, the international ImMunoGeneTics information system® (2004, unknown): “The IMGT (cid:1) information system consists of databases, tools and Web resources (3).”
Ensembl 2008 (2007, methodology): “We now align annotated segments from the IMGT database (17) for mouse and human.”
Immunoglobulin Analysis Tool: A Novel Tool for the Analysis of Human and Mouse Heavy and Light Chain Transcripts (2012, background): “IgAT is available free readily yields the necessary data to allow”
IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences (2005, unknown): “IMGT/LIGM-DB is the first and the largest database of IMGT , the international ImMunoGeneTics information system (4,5).”
Antibody Structure and Function: The Basis for Engineering Therapeutics (2019, unknown): “On the other hand, the IMGT convention excludes residues 35 and 50 from CDRs H1 and H2, respectively, although they are often involved in antigen binding.”
T cell fate and clonality inference from single cell transcriptomes (2016, methodology): “To generate these fasta files, nucleotide sequences for all mouse V and J genes were downloaded from The International ImMunoGeneTics information system 38 (IMGT, www.imgt.org).”
SAbDab: the structural antibody database (2013, background): “These include: H and L chain identiﬁers, the bound state of the F AB , the IMGT subgroup gene annotations, the Chothia numbered sequence of each chain, information about each CDR and the orientation measures between the VH and VL domains.”
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis (2008, background): “fr) (1), is the international reference in immunogenetics and immunoinformatics.”