IMGT®, the international ImMunoGeneTics information system®

By Marie-Paule Lefranc, Véronique Giudicelli, Chantal Ginestoux, Joumana Jabado-Michaloud, Géraldine Folch, Fatena Bellahcene, Yan Wu, Elodie Gemrot, Xavier Brochet, Jérôme Lane and 4 more. Nucleic Acids Res., 2004

490 citations recorded by the source corpus.

IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT® the global reference in immunogenetics and immunoinformatics. IMGT® is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT® provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT® consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10 000 HTML pages of synthesis and knowledge. IMGT® is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/acdaf7d9d29dce86c5b40a940362c93c1beb447a

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In Immunology

Citations in the corpus

Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity (2016, unknown): “Somatic mutations were retrieved using the IMGT database [34].”
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis (2008, background): “IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) ( 1 ), is the international reference in immunogenetics and immunoinformatics.”
RosettaAntibodyDesign (RAbD): A general framework for computational antibody design (2017, unknown): “…[54], which is updated monthly and contains CDR sequences and cluster identifications for all antibodies in the PDB. PyIgClassify includes identification of species and IMGT germline V regions [55], and is provided as a relational database for use in antibody structure prediction and design.”