IMGT/LIGM-DB, the IMGT® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences

By Véronique Giudicelli, Patrice Duroux, Chantal Ginestoux, Géraldine Folch, Joumana Jabado-Michaloud, D. Chaume, Marie-Paule Lefranc. Nucleic Acids Res., 2005

307 citations recorded by the source corpus.

IMGT/LIGM-DB is the IMGT® comprehensive database of immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human and other vertebrate species. It was created in 1989 by LIGM, Montpellier, France and is the oldest and the largest database of IMGT®. IMGT/LIGM-DB includes all germline (non-rearranged) and rearranged IG and TR genomic DNA (gDNA) and complementary DNA (cDNA) sequences published in generalist databases. IMGT/LIGM-DB allows searches from the Web interface according to biological and immunogenetic criteria through five distinct modules depending on the user interest. For a given entry, nine types of display are available including the IMGT flat file, the translation of the coding regions and the analysis by the IMGT/V-QUEST tool. IMGT/LIGM-DB distributes expertly annotated sequences. The annotations hugely enhance the quality and the accuracy of the distributed detailed information. They include the sequence identification, the gene and allele classification, the constitutive and specific motif description, the codon and amino acid numbering, and the sequence obtaining information, according to the main concepts of IMGT-ONTOLOGY. They represent the main source of IG and TR gene and allele knowledge stored in IMGT/GENE-DB and in the IMGT reference directory. IMGT/LIGM-DB is freely available at .

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/d42d2bb4342a0db88e5448dc915ad6b9044c187b

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In Immunology

Citations in the corpus

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design (2017, unknown): “From this classification, we developed the PyIgClassify database [54], which is updated monthly and contains CDR sequences and cluster identifications for all antibodies in the PDB. PyIgClassify includes identification of species and IMGT germline V regions [55], and is provided as a relational data”
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis (2008, background): “…detailed analysis of the junction (performed even if cystein 104 and/or phenylalanine/tryptophan 118 are mutated) (7) and for the optional display of the eligible D genes and alleles, and IMGT/Automat (9) for the full annotation of the V-J-REGION or V-D-J-REGION in an IMGT/LIGM-DB-like format (13).”
The Ensembl gene annotation system (2016, background): “The IMGT genes are aligned to the genome using Exonerate and are then merged with our gene annotations.”
LYRA, a webserver for lymphocyte receptor structural modeling (2015, methodology): “Additional nucleic acid sequences for and chains were then downloaded from the IMGT/LIGM-DB (22), translated to amino acid sequences and aligned using the seed HMM profiles.”
IMGT®, the international ImMunoGeneTics information system® (2004, methodology): “IMGT/LIGM-DB (24) is the comprehensive IMGT database of IG and TR nucleotide sequences from human and other vertebrate species, with translation for fully annotated sequences, created in 1989 by LIGM, Montpellier, France, on the Web since July 1995.”