Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
By S. Padayatty, He Sun, Yaohui Wang, H. Riordan, S. Hewitt, A. Katz, R. Wesley, M. Levine. Annals of Internal Medicine, 2004
952 citations recorded by the source corpus.
Subfields: Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/17a8c266587da1107fc9f4f41e9306abd947e799
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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- S. Padayatty
- Jihye Yun
- Vikramjit Khangoora
- Juan Du
- Edouard Mullarky
- Racquel Rivera
- P. Marik
- M. Hooper
Citations in the corpus
- Vitamin C physiology: the known and the unknown and Goldilocks (2016, positive): “Data from these in vitro vitamin C transport studies were used to estimate plasma vitamin C concentrations in humans using a mathematical model based on data from normal subjects (Graumlich et al., 1997, Padayatty et al., 2004).”
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice (2008, background): “Third, complementary and alternative medicine practitioners continue to administer high-dose ascorbate off label, without apparent toxicity when patients are properly screened for normal renal function and absence of glucose-6-phosphate dehydrogenase deficiency, iron overload, and oxalate nephropath”
- Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “Because of the limited affinity of SVCT1 for ascorbate, plasma ascorbate concentrations are tightly controlled [8].”
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH (2015, background): “are only achievable via intravenous administration, not via oral administration (30, 31).”
- Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before‐After Study (2017, background): “Because of the saturable intestinal transporter (sodium-vitamin C transporter-1),(20,83) oral administration of doses as high as 1,500mg cannot restore normal serum levels.(20) To achieve normal serum vitamin C levels in critically ill patients, a daily dose of more than 3 g is required.”