Long-circulating and target-specific nanoparticles: theory to practice.

By S. Moghimi, A. C. Hunter, J. C. Murray. Pharmacological Reviews, 2001

3,464 citations recorded by the source corpus.

The rapid recognition of intravenously injected colloidal carriers, such as liposomes and polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development for "Kupffer cell-evading" or long-circulating particles. Such carriers have applications in vascular drug delivery and release, site-specific targeting (passive as well as active targeting), as well as transfusion medicine. In this article we have critically reviewed and assessed the rational approaches in the design as well as the biological performance of such constructs. For engineering and design of long-circulating carriers, we have taken a lead from nature. Here, we have explored the surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition. Our analysis is then centered where such strategies have been translated and fabricated to design a wide range of particulate carriers (e.g., nanospheres, liposomes, micelles, oil-in-water emulsions) with prolonged circulation and/or target specificity. With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/16fc7e4b7309a02d0a0fd140e24cc609c243644f

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In Biomaterials

1. S. Mitragotri
2. O. Farokhzad
3. N. Bertrand
4. A. Anselmo
5. Omid Veiseh
6. J. Gunn
7. S. Sahoo
8. Zhuang Liu

In Molecular Biology

1. O. Farokhzad
2. S. Mitragotri
3. Zhuang Liu
4. Hongjie Dai
5. Robert Langer
6. N. Bertrand
7. S. Sahoo
8. Xiaoyuan Chen

Citations in the corpus

• DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. (2008, background): “More importantly is the potential for the application of Ag NPs in the treatment of diseases that need constant drug concentration in the blood or targeting of specific cells or organs (Moghimi et al., 2001; Panyam and Labhasetwar, 2003).”
• The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “Activation of the cascade can lead to covalent opsonisation of the surface of particulate nanocarriers [35].”
• Nanomedicine: current status and future prospects (2005, background): “This is particularly true for rigid or nondeformable particles whose size exceeds the width of the cell slits (200–250 nm) (24).”
• Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. (2011, methodology): “[136] performed an extensive study of the opsonisation process (adsorption of plasma protein) based on theNP's surface charge, size andhydrophilicity/hydrophobicity.”