Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression.

By David K. Welsh, Seung-Hee Yoo, A. C. Liu, J. Takahashi, Steve A. Kay. Current Biology, 2004

726 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/16f32e3a01401c2726c6a9badf966bf7da0755bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. C. Green
5. Ethan D. Buhr
6. J. Mohawk
7. Steve A. Kay
8. David K. Welsh

In Plant Science

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. Ethan D. Buhr
5. C. Green
6. U. Schibler
7. C. Dibner
8. Steve A. Kay

Citations in the corpus

• Molecular components of the Mammalian circadian clock. (2013, background): “If viewed at the single-cell level, the molecular clockwork of transcription and translation can be observed as autonomous single-cell oscillators (Nagoshi et al. 2004; Welsh et al. 2004).”
• Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors (2005, background): “…a major role in orchestrating rhythmicity throughout the organism, most tissues and even isolated cells possess their own and ostensibly similar circadian clocks (Balsalobre et al., 1998; Yamazaki et al., 2000; Nagoshi et al., 2004; Welsh et al., 2004; Yoo et al., 2004; Carr and Whitmore, 2005).”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “…discovery of peripheral oscillators (Balsalobre et al. 1998, Yamazaki et al. 2000, Yoo et al. 2004) and the apparent ubiquity of clock mechanisms (Yagita et al. 2001), a critical question arises concerning the similarity and differences in the SCN pacemaker as compared with peripheral…”
• Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “PER2::LUC imaging of cultured fibroblasts reveal that individual fibroblast oscillations persist without damping, and that the damping observed at the population level is due to desynchrony among cells (6).”
• Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, methodology): “1Department of Biochemistry, The Scripps Research Institute, La Jolla, CA 92037, USA 2Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA 3Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA 4Veterans Affairs San Diego Healthcare System”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Using single-cell measurements of fibroblasts engineered with either circadian-driven bioluminescent or fluorescent reporter genes, cell-autonomous circadian rhythms can be observed that persist with undiminished amplitude for many days in vitro”
• Molecular components of the mammalian circadian clock. (2006, background): “If viewed at the single-cell level, the molecular clockwork of transcription and translation can be observed as autonomous single-cell oscillators (Nagoshi et al. 2004; Welsh et al. 2004).”
• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, result): “Single-cell recordings and mathematical analysis of bioluminescence cycles generated by cell populations revealed that fibroblasts harbor self-sustained, cell-autonomous oscillators (107, 210) (Figure 4), in keeping with the observations made with peripheral tissue explants (182).”