Intra- and Interspecific Variation in Primate Gene Expression Patterns

By Wolfgang Enard, P. Khaitovich, J. Klose, S. Zöllner, F. Heissig, Patrick Giavalisco, K. Nieselt-Struwe, E. Muchmore, A. Varki, R. Ravid and 3 more. Science, 2002

840 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/160903594f5971be55ff83ab1acbe9dcfa3e8c14

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Citations in the corpus

Modularity in cognition: framing the debate. (2006, background): “Moreover, there appear to be relatively large differences in patterns of gene expression in human and chimpanzee brains, which could lead to substantial differences in brain organization (Enard et al., 2002).”
Variation in gene expression within and among natural populations (2002, background): “In humans there is a large variation in gene expression between individuals; in a global comparison of mRNA levels of chimpanzees and humans, there was greater variation within the human population than between human and chimpanzee population”
The model organism as a system: integrating 'omics' data sets (2006, background): “One question that is of fundamental interest is what cellular factors distinguish species, and are therefore likely to have had roles in speciation events, particularly those of close evolutionary relatives? For example, as the chimpanzee and human genome sequences share ∼99% identity, what other ce”
The evolutionary significance of cis-regulatory mutations (2007, background): “The first such analysis by Enard and colleagues indicated a greater degree of evolutionary change in transcription in brain than in liver, specifically on the human branch of a three-species comparison (human compared with chimpanzee, and rooted with macaque”
Functional organization of the transcriptome in human brain (2008, neutral): “# [1] "B_123233_DLPFC" "B_123253_OFC" "B_123256_OFC" "K_91_BA46" [5] "H_86938_BA9" "H_86951_BA9"”
The evolution of transcriptional regulation in eukaryotes. (2003, background): “…1-or 2-dimensional protein gels in a variety of organisms: Zea mays (Burstin et al. 1994; Damerval et al. 1994; de Vienne et al. 2001), Pinus pinaster (Costa and Plomion 1999), Glycine max (Gerber, Fabre, and Planchon 2000), Mus musculus (Klose et al. 2002), and Homo sapiens (Enard et al. 2002 a ).”
The origin and evolution of model organisms (2002, background): “Similarly, knowing that our closest relative is the chimpanzee is crucial for identifying genetic changes in coding and regulatory genomic regions that are unique to humans, and are possibly associated with traits such as intelligenc”