Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

By Taija Mäkinen, L. Jussila, Tanja Veikkola, Terhi Karpanen, M. Kettunen, K. Pulkkanen, R. Kauppinen, D. Jackson, H. Kubo, S. Nishikawa and 2 more. Nature Medicine, 2001

816 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/15ea19aab9c0ccb27b9010b20b43a1e3c9384b54

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. H. Wiig
2. M. Swartz
3. K. Alitalo
4. T. Tammela
5. Seppo Ylä-Herttuala
6. S. Bhardwaj
7. H. Roy
8. Rakesh K. Jain

In Oncology

1. K. Alitalo
2. H. Wiig
3. M. Swartz
4. T. Tammela
5. Rakesh K. Jain
6. M. Shibuya

In Physiology

1. K. Alitalo
2. T. Tammela

Citations in the corpus

• CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation (2014, methodology): “Ba/F3-VEGFR/EpoR Assays The Ba/F3-hVEGFR-3/EpoR,(13) Ba/F3-mVEGFR-2/EpoR(14) and Ba/ F3-hVEGFR-2/EpoR bioassays were performed with conditioned cell culture medium as described.(15) Stimulation of VEGFR-3 Phosphorylation”
• Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. (2005, neutral): “More recent studies show that lymphangiogenesis can be stimulated or inhibited by agonists or antagonists of VEGFR-3 signaling independent of angiogenesis (32, 33).”
• Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Wiig, unpublished data), another model of primary lymphedema (281).”
• Biology of vascular endothelial growth factors (2006, background): “2) Transgenic mice overexpressing a soluble VEGFR-3-Ig fusion protein in the skin lack dermal lymphatic vessels [46].”
• Lymphangiogenesis: Molecular mechanisms and future promise. (2010, background): “5 onward in mouse embryos results in severe hypoplasia of the lymphatic vessels (Makinen et al., 2001), indicating that VEGF-C/VEGFR-3 signaling plays a key role in further development of the lymphatic vascular tree following formation of the lymph sacs.”