Lipid rafts Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.R200021-JLR200
By L. Pike. Journal of Lipid Research, 2003
1,123 citations recorded by the source corpus.
Lipid rafts are subdomains of the plasma membrane that contain high concentrations of cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the membrane that are resistant to extraction with nonionic detergents. Rafts appear to be small in size, but may constitute a relatively large fraction of the plasma membrane. While rafts have a distinctive protein and lipid composition, all rafts do not appear to be identical in terms of either the proteins or the lipids that they contain. A variety of proteins, especially those involved in cell signaling, have been shown to partition into lipid rafts. As a result, lipid rafts are thought to be involved in the regulation of signal transduction. Experimental evidence suggests that there are probably several different mechanisms through which rafts control cell signaling. For example, rafts may contain incomplete signaling pathways that are activated when a receptor or other required molecule is recruited into the raft. Rafts may also be important in limiting signaling, either by physical sequestration of signaling components to block nonspecific interactions, or by suppressing the intrinsic activity of signaling proteins present within rafts. This review provides an overview of the physical characteristics of lipid rafts and summarizes studies that have helped to elucidate the role of lipid rafts in signaling via receptor tyrosine kinases and G protein-coupled receptors.
Subfields: Cardiology and Cardiovascular Medicine, Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/15b850fa30117b250ee392638c37b93fbebf83b5
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In Cardiology and Cardiovascular Medicine
In Cell Biology
In Molecular Biology
- Doralicia Casares
- P. Calder
- I. Levitan
- S. Keller
- Raphael Zidovetzki
- C. A. Rosselló
- S. Veatch
- P. Escribá
Citations in the corpus
- Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “, the receptor) to the lipid raft [63].”
- Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. (2003, background): “Lipid rafts have been associated with important biological processes such as endocytosis, adhesion, signaling, protein transport, apoptosis, and cytoskeleton organization (Deans et al., 2002; Edidin, 2003; Pike, 2003; Tsui-Pierchala et al., 2002).”
- Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. (2007, background): “Morphology, size, density and molecular composition of rafts in cellular membranes are still controversial, as summarized recently in several excellent reviews [33,35–47] and a detailed discussion of these topics is beyond the scope of the current review.”
- Mechanisms of action of (n-3) fatty acids. (2012, background): “, colocalizing) various signaling components in response to a stimulus, so facilitating their interaction (84).”