Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

By M. Michaud, I. Martins, Abdul Qader Sukkurwala, Sandy Adjemian, Yuting Ma, P. Pellegatti, Shensi Shen, Oliver Kepp, Marie Scoazec, G. Mignot and 9 more. Science, 2011

1,334 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/1587e6427a0460c2f00a9ecd93539d3dc450bcce

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In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Alec C. Kimmelman
5. D. Tang
6. I. Slaninová
7. R. Kang
8. P. Codogno

In Physiology

1. Guido Kroemer
2. L. Galluzzi
3. Beth Levine
4. Alec C. Kimmelman
5. M. Smyth
6. D. Rubinsztein
7. L. Zitvogel
8. P. Codogno

Citations in the corpus

• Spermidine in health and disease (2018, background): “However, premortem autophagy also promotes immune recognition of cancer cells because it facilitates the release of adenosine 5′-triphosphate (ATP), which serves as a chemotactic factor for myeloid cells, including dendritic cell precursors (103, 104).”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “On the other hand, CD8+ T cells induce cancer cell pyroptosis by secreting GZMA and GZMB, which can cleave GSDMB/D/E. NLRP3 inflammasomes promote IL-18 and IL-1β secretion, which have tumor-promoting or antitumor effect dependent on the context of TME. c Significant lipid peroxidation activity can o”
• Immunogenic cell death and DAMPs in cancer therapy (2012, background): “These authors showed that a recombinant N-terminal fragment of CRT (39-272) is a potent inducer of activation and maturation of B cells and macrophages and can trigger Ig class switching in B cells without T cell help in vitro and in vivo72.”
• Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. (2016, background): “Certain cytotoxic chemotherapeutic agents are thought to have immunogenic properties, such as 5-flurouracil which may decrease myeloid-derived suppressor cells (MDSC) [88] and increase effector T cells at the tumor microenvironment [89], and oxaliplatin which induces immunogenic cell death [90].”
• Targeting autophagy in cancer (2018, background): “Michaud et al demonstrated that autophagy was dispensable for chemotherapy-induced cell death but was required for its immunogenicity, because only autophagy-competent cells attracted dendritic cells and T lymphocytes into the tumor.(93) Those authors propose that autophagy is essential Figure 2.”