Decline in skeletal muscle mitochondrial function with aging in humans.

By K. Short, Maureen L. Bigelow, J. Kahl, Ravinder Singh, Jill M. Coenen-Schimke, S. Raghavakaimal, K. S. Nair. Proceedings of the National Academy of Sciences of the United States of America, 2005

950 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/151f6b541115dd96c395ab20b521c31a3a123b06

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Citations in the corpus

Fiber types in mammalian skeletal muscles. (2011, neutral): “The fiber type transition during aging is accompanied by a loss of mitochondrial ATP production resulting from reduced abundance of mitochondrial DNA and reduced content of several mitochondrial proteins (732).”
Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling (2010, neutral): “Major mitochondrial age-related changes are observed in multiple tissues and include decreased Dψm, increased ROS production and an increase in oxidative damage to mtDNA, proteins, and lipids [11-14].”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, positive): “In the case of DNA, oxidative damage to mitochondrial and nuclear nucleic acids is significantly increased in all major tissues in aged organisms, including mice (93), rats (93, 269), hamsters (255), and humans (79, 241).”
Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, positive): “It is possible that tissue-specific effect of aging on mtDNA abundance is related to the status of aerobic activity [156, 158], as aerobic exercise has been shown to enhance muscle mtDNA abundance in both human and mouse [162–164].”
Skeletal muscle performance and ageing (2017, positive): “88 This decline may result in lower mitochondrial muscle protein synthesis rates in older adults.”
The role of mitochondria in aging. (2013, positive): “The RC capacity has also been reported to decline with age in human liver, heart, and skeletal muscle (20, 21).”
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies (2016, positive): “to insulin resistance and obesity/diabetes [66,118,119].”