Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.

By J. Curtin, E. Quint, V. Tsipouri, R. Arkell, B. Cattanach, A. Copp, D. Henderson, N. Spurr, P. Stanier, E. Fisher and 5 more. Current Biology, 2003

642 citations recorded by the source corpus.

Subfields: Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/150717943e0b6451785fa98ca366c6770b139efb

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In Molecular Biology

1. S. Goetz
2. N. Katsanis
3. K. Anderson
4. Jennifer M. Halbleib
5. W. Nelson
6. J. R. Lupski
7. C. Niessen

Citations in the corpus

• The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “Although mammalian non-canonical Wnt pathway mutants fail to close the entire neural tube caudal to the forebrain, neural patterning in these mutants is relatively norma”
• Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. (2006, background): “2005), and mutant Celsr1 disrupts stereocilia architecture (Curtin et al. 2003).”
• Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates (2005, background): “Known mouse PCP mutants, including those with mutations of the core PCP orthologs Vangl2 (Van Gogh) and Celsr1 (Flamingo), as well as Scrb1 (Scribble) and PTK7, all have the neural tube defect craniorachischisis and disrupted stereociliary bundle organization in cochlear sensory hair cell”