A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

By Tobias Goldmann, P. Wieghofer, P. Müller, Yochai Wolf, Diana Varol, S. Yona, S. Brendecke, Katrin Kierdorf, O. Staszewski, Moumita Datta and 4 more. Nature Neuroscience, 2013

639 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/15051417802e941c6e03e4ea752b87586784a1a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Dominic Grün

In Immunology

1. A. Mildner
2. Steffen Jung
3. C. Varol
4. Marco Prinz
5. G. Randolph
6. M. Guilliams
7. Florent Ginhoux
8. F. Geissmann

In Neurology

1. Steffen Jung
2. Marco Prinz
3. Stephanie Armbruster

Citations in the corpus

• Macrophages: development and tissue specialization. (2015, background): “MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.”
• Origin and Functions of Tissue Macrophages (2014, background): “SNPs in genes encoding CD33 (a phagocytosis inhibitor) or TREM2 (which mediates neuronal uptake) are associated with Alzheimer’s disease, lending clinical credence to the idea that impaired phagocytotic clearance of plaque promotes disease progression (Griciuc et al., 2013; Guerreiro et al., 2013).”
• Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation (2019, background): “These suggested major roles of microglia, including the expression of proinflammatory mediators and effector molecules at the peak of disease (30, 60) and the removal of debris, which allows proper remyelination during the recovery phase (49, 61).”