Mitochondrial dynamics and inheritance during cell division, development and disease

By Prashant Mishra, D. C. Chan. Nature reviews. Molecular cell biology, 2014

974 citations recorded by the source corpus.

During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features — including their own genome and a maternal mode of germline transmission — that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion–fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/14fe3d467692c032b6a07ad6d7ad9ba748597224

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Prashant Mishra
2. Bor Luen Tang
3. G. Shadel
4. D. C. Chan
5. W. Ding
6. Hsiuchen Chen
7. B. Westermann

In Molecular Biology

1. Prashant Mishra
2. Bor Luen Tang
3. G. Shadel
4. W. Ding
5. D. C. Chan
6. T. Horvath
7. Hsiuchen Chen
8. B. Westermann

Citations in the corpus

• Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “Though often depicted as small round or oval structures, they are instead usually dynamic, branched networks that constantly fuse and divide under control of specific fission and fusion machineries (Mishra and Chan, 2014).”
• Sirt1 and the Mitochondria (2016, background): “Mitochondria are dynamic organelles, and inheritance occurs by partitioning existing mitochondria between daughter cells in dividing cells (Mishra and Chan, 2014).”
• Mitochondrial dynamics and mitochondrial quality control (2014, background): “Drp1 is a cytosolic protein that can be recruited to the outer mitochondrial membrane to constrict mitochondria resulting in eventual division of a mitochondrion into two separate organelles.”
• Metabolic regulation of mitochondrial dynamics (2016, background): “From yeast to mammals, these dynamic behaviors have been shown to be clearly important in both normal physiology and disease states (Labbé et al., 2014; Mishra and Chan, 2014).”