Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.

By Alicia R Folgueras, A. Pendás, Luis M. Sánchez, C. López‐Otín. International Journal of Developmental Biology, 2004

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Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation (2006, background): “The exocite processings and cleavages have been found to result usually in small-size molecules or peptides (59,64,80), the effects of which may in fact be clearly more potent than the full-size parent or native molecule (3,5,59).”
Matrix metalloproteinases. (2010, methodology): “Many MMPs are produced by endothelial cells and is important in the formation of new blood vessels in physiological conditions [123].”
Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “Indeed, secreted MMPs (MMPs-1, -2, -3, 7-, -8, -9, -10, -11, -13) as well as membrane-bound MT-MMPs are critical for the formation of cancer metastases, their invasion into the brain, and the formation of secondary tumors, and MMPs participate in most of the steps of the metastasis process (Figure 7”
Matrix metalloproteinases and tumor metastasis (2006, background): “Also MMP-11 was shown to generate a bioactive fragment from α1-proteinase inhibitor which diminished natural killer sensitivity, thereby enhancing tumor growth and invasiveness in vivo [19, 167].”