Designed multiple ligands. An emerging drug discovery paradigm.

By R. Morphy, Z. Rankovic. Journal of Medicinal Chemistry, 2005

1,074 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Virtual screening strategies in drug discovery: a critical review. (2013, background): “A better insight into the disease-relevant targets and pathways leading to better therapeutic approaches are further benefits of chemogenomics applications [162].”
Drugs, their targets and the nature and number of drug targets (2006, background): “However, there is an increasing readiness to challenge this paradig”
Automated design of ligands to polypharmacological profiles (2012, background): “However, designing drugs with a specific multi-target profile – to achieve either exquisite selectivity over other drug targets or a desired polypharmacology – is a complex and exceedingly difficult task for medicinal chemistry 8 .”