Drugs, their targets and the nature and number of drug targets

By P. Imming, C. Sinning, A. Meyer. Nature reviews. Drug discovery, 2006

762 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/83f9922627f1c6e899b96d12698c6a9d84d47971

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

In Organic Chemistry

In Pharmacology

Citations in the corpus

Synergy research: approaching a new generation of phytopharmaceuticals. (2009, background): “Imming et al. (2006) have listed possible important drug targets based on approved drug H.”
DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction Sites (2015, background): “Whereas almost all drugs currently in the clinic inhibit one of several “traditional” target classes (G protein-coupled receptors, enzymes, nuclear receptors, transporters, and ion channels) [13, 14], protein-protein interactions now stand among a broad new emerging class of “non-traditional” target”
Mechanisms of drug combinations: interaction and network perspectives (2009, neutral): “jpg" NDATA ITEM> ]> In recent years, drug discovery efforts have primarily focused on identifying agents that modulate preselected individual target”
Meta-QSAR: a large-scale application of meta-learning to drug design and discovery (2017, methodology): “Wealso used drug target groupings (Imming et al. 2006), such as ’drug target classes’, and ’the preferred name groupings’, as meta-features.”
SuperTarget and Matador: resources for exploring drug-target relationships (2007, background): “For some drugs even the primary targets are still unknown, for example, Diloxanide, Niclosamide and Ambroxol are administered successfully although their effect on human metabolism is still not clarified at a molecular level (1).”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, background): “group, and the voltage-gated ion channels in the transporter protein group (Imming et al., 2006; Rask-Andersen et al., 2011).”
DrugBank: a knowledgebase for drugs, drug actions and drug targets (2007, neutral): “(17) and Overington et al .”
How were new medicines discovered? (2011, background): “Since the dawn of the genomics era in the 1990s, the main focus of drug discovery has been on drug targets, which are typically proteins that appear to have a key role in disease pathogenesi”
Molecular Systems Biology Peer Review Process File Indi: a Computational Framework for Inferring Drug Interactions and Their Associated Recommendations Transaction Report (neutral): “…(Zhang et al, 2009), and pharmacodynamic © 2012 EMBO and Macmillan Publishers Limited interactions, where the effects of one drug are modified by the effect of another on its site of action or by affecting the same or cross-talking signaling pathways (Jonker et al, 2005; Imming et al, 2006).”
Artificial intelligence in radiology (2018, neutral): “On the other hand, we find that many safe and effective US Food and Drug Administration (FDA)-approved drugs have unknown mechanisms of action 104,105 .”