Molecular, pharmacological and functional diversity of 5-HT receptors.

By D. Hoyer, J. Hannon, G. Martin. Pharmacology, Biochemistry and Behavior, 2002

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Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “Of the 14 5-HT receptors identified, all except 5-HT3 (ligand-gated ion channel) are G protein-coupled receptors (430).”
Serotonin syndrome. (2014, background): “In addition to the brain, the 5-HT2A receptor is relatively abundant in peripheral organs where it mediates the constrictive response of the smooth muscle (bronchi, uterus, urinary tract), vasoconstriction/vasodilation, platelet aggregation, and increases capillary permeability (Pytliak et al. 2011;”
Neuroendocrine pharmacology of stress. (2003, background): “Members of the 5-HT1 receptor family (5-HT1A, 5HT1B, 5-HT1D, 5-HT1E, 5-HT1F) are mainly coupled to Gi/o/ z proteins, members of the 5-HT2 family (5-HT2A, 5-HT2B, 5-HT2C) are coupled to Gq/11 proteins and all other receptor families are coupled to Gs proteins (Albert and Tiberi, 2001; Hoyer et al., 2”
Serotonin, serotonin receptors and their actions in insects (2014, background): “5-HT4, 5HT6 and 5-HT7 couple to Gs-proteins; the Gαs-subunit stimulates adenylyl cyclase activity and hence increases the intracellular cAMP levels (Table 1) ([14,63-65,73,76]).”