GABA regulates synaptic integration of newly generated neurons in the adult brain

By S. Ge, E. Goh, Kurt Sailor, Yasuji Kitabatake, Guo-li Ming, Hongjun Song. 2006

1,207 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience, Neuroscience

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Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “Bergami et al., 2008; Waterhouse et al., 2012 GABA Neurotransmitter DG Ge et al., 2006 Glutamate Neurotransmitter SVZ Platel et al., 2010 WNT Morphogen DG Lie et al., 2005; Kuwabara et al., 2009 INTRACELLULAR FACTORS NFATc4 Transcription factor DG Quadrato et al., 2012 NF-KappaB p50 Transcription…”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “They are initially tonically activated by ambient GABA released from local interneurons (Bhattacharyya et al., 2008; Ge et al., 2006), followed by GABAergic synaptic inputs, and finally glutamatergic synaptic inputs (Espósito et al., 2005; Ge et al., 2006; Overstreet-Wadiche et al., 2006b) and…”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Notably, these cells are tonically activated by ambient GABA (γ-aminobutyric acid”
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “Toward the end of the second week, GABA inputs become progressively hyperpolarizing, and the adult-born neurons begin receiving functional glutamatergic depolarizing afferents [11,29,40,41], a process that occurs in parallel with the formation of dendritic spines.”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Newly generated granule neurons born in the SGZ migrate only a short distance to the granule cell layer, where they extend dendrites to the molecular layer and an axon along the mossy fibre path and integrate functionally into the circuitry of the dentate gyrus (van Praag et al. 2002; Jessberger & K”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “Other , nonexclusive candidate mechanisms include extrasynaptic glutamate or GABA ( Ge et al .”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, positive): “Immunohistology, In Situ Hybridization, Confocal Imaging, and Analysis Coronal brain sections (40 mm thick) were prepared from injected mice and processed for immunostaining as described (Ge et al., 2006).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, et al. GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “The functional integration of newborn granule cells into the existing hippocampal circuitry have been studied in much detail by electrophysiological recording of these cells, either labeled by engineered onco-retrovirus (Song et al., 2005; Ge et al., 2006) or marked in transgenic reporter mice (Over”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, positive): “These results indicate that, although GABAergic signaling at early stage is required for normal dendritic maturation (Ge et al., 2006), excessive amounts of GABAergic signaling in hAPP mice are detrimental.”
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb (2013, background): “Consistent with previous electrophysiological studies (26, 32), newborn neurons in the adult DG become first innervated by interneurons in the SGZ and the hilus, and presynaptic connections from interneurons residing in the ML arrive slightly later, perhaps reflecting the maturation of the dendritic”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, neutral): “There is considerable evidence that these adult-born granule neurons are physiologically functional (Wang et al., 2000; Snyder et al., 2001; van Praag et al., 2002; Esposito et al., 2005; Ge et al., 2006) and contribute to hippocampus-dependent behaviors (Shors et al.”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “…al., 2006; Zhao et al., 2006; Toni et al., 2007, 2008; Faulkner et al., 2008), their unique electrophysiological properties (SchmidtHieber et al., 2004; Espósito et al., 2005; Ge et al., 2006, 2007) and their preferential incorporation into memory networks (Kee et al., 2007; Tashiro et al., 2007).”
Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus (2013, background): “At early stages, GABA depolarizes neurons because of high concentrations of intracellular Cl (30).”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “Newborn neurons in the dentate gyrus go through several developmental stages with distinctive physiological and morphological properties (Figures 2 and 4) (Esposito et al., 2005; Ge et al., 2006; Overstreet Wadiche et al., 2005; Zhao et al., 2006).”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, methodology): “Four weeks after injection, when the newborn neurons were fully developed and integrated (Aimone et al., 2006; Ge et al., 2006a; Lie et al., 2004; Ming and Song, 2005), GFP neurons were found to have much less elaborate dendrites in apoE4-KI mice than in apoE3-KI, wild-type, and apoE-KO mice (Figure”