Neutrophil kinetics in health and disease

By C. Summers, S. Rankin, A. Condliffe, Nanak R. Singh, A. Peters, E. Chilvers. Trends in immunology, 2010

1,209 citations recorded by the source corpus.

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived with a circulating half life of 6–8 h and hence are produced at a rate of 5 × 1010–10 × 1010 cells/day. Tight regulation of these cells is vital because they have significant histotoxic capacity and are widely implicated in tissue injury. This review outlines our current understanding of how neutrophils are released from the bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis, the relative size and role of the freely circulating and marginated (i.e. slowly transiting) pools within the vascular compartment, and the events that result in the uptake and removal of circulating neutrophils. We also review current understanding of how systemic stress and inflammation affect this finely balanced system.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/138de4cbf81e7ee69a2b193e26fad37e37a9d1fc

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Citations in the corpus

Reactive Oxygen Species and Neutrophil Function. (2016, background): “In contrast, neutrophils at inflammatory sites are exposed to host and pathogen-derived factors that delay spontaneous apoptosis, enabling them to participate fully in the inflammatory process (109).”
Coordinated regulation of myeloid cells by tumours (2012, background): “Tumour cell-derived TNF was partially responsible for this polarization through its induction of macrophage scavenger receptor types I and I”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “The process of AB formation might, however, only be important for large cells that are difficult to engulf in their intact state, since it is known that cells such as neutrophils do not readily form ABs, but are rather phagocytized whole [103,104].”
The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “At the lesion site, neutrophils help potentiate the inflammatory cascade (66, 145) by activating other immune cells and glia through the release of proinflammatory cytokines and chemokines (60, 371, 372, 396), ROS, and proteases (159).”
Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Post-mitotic bone marrow neutrophils constitute 95% of the neutrophils in the body [2,3] and this reserve is easily mobilized and recruited rapidly to sites of infection.”
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011, background): “Thus, either the rate of production of neutrophils or the validity of the assumptions made to estimate the duration of neutrophils in the circulation must be reconsidere”