Regulation of the Cdk inhibitor p27 and its deregulation in cancer

By J. Slingerland, M. Pagano. Journal of Cellular Physiology, 2000

779 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1371dd74ef2fc1e3cbe6890f403eee79f8216737

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Citations in the corpus

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest (2002, background): “In up to 50% of human cancers, reduced p27 protein is associated with a poor prognosi”
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization (2002, background): “2b ), another short-lived tumour suppressor protein whose stability is also regulated by the ubiquitination pathwa”
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis (2007, background): “p27 abundance is governed by transcription, translation, phosphorylation and ubiquitin-mediated proteolysi”
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. (2002, background): “As noted, the level of p27 is markedly reduced in several cancers, including breast, colorectal, and prostate carcinomas, and in many of these cases there was a strong correlation between the low level of p27 and the aggressiveness of the disease: tumor grading, clinical staging, and poor prognosis ”
CDK inhibitors: cell cycle regulators and beyond. (2008, positive): “…protein are frequently observed in a broad array of human malignancies, including carcinomas of the breast, colon, prostate, ovary, lung, brain, stomach, and others, and this is associated with increased tumor aggressiveness (Besson et al., 2004a; Blain et al., 2003; Slingerland and Pagano, 2000).”
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (2008, background): “Although p27 is not a classic tumour suppressor like p53, as it is rarely mutated or deleted in human cancer”
14‐3‐3 suppresses the nuclear localization of threonine 157‐phosphorylated p27Kip1 (2004, background): “A reduced p27 expression has been consistently observed in many human cancers and is correlated with tumor progres- sion, while cytoplasmic localization of p27 in several cancers has also been implicated in promoting cell proliferation (reviewed in Slingerland and Pagano, 2000).”