Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.

By Rafal Ciosk, M. Shirayama, Andrej Shevchenko, Tomoyuki U. Tanaka, A. Tóth, Kim Nasmyth. Molecules and Cells, 2000

774 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1368fac5439c9cbacd8e3fa4a2a6e033925f2978

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Citations in the corpus

NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome (2004, background): “Many of the fungal homologs have crucial chromosomal roles: Saccharomyces cerevisiae Scc2 and Schizosaccharomyces pombe Mis4 in sister chromatid cohesio”
Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B (2004, background): “In a BLAST search of the National Center for Biotechnology Information database, NIPBL also had substantial homology with the Saccharomyces cerevisiae sister chromatid cohesion protein 2, which forms a complex with SCC4 and is required for the association of the cohesin complex with chromosome”
Molecular architecture of SMC proteins and the yeast cohesin complex. (2002, methodology): “Micrococcal nuclease diges-whereas Smc1/3 dimers missing only Smc3’s head bound Scc1’s C-terminal but not N-terminal fragment tion was used to release cohesin from chromatin (Ciosk et al., 2000), which had previously been separated from(Figure 5A).”
Chromatin organization by an interplay of loop extrusion and compartmental segregation (2017, background): “Upon removal of the cohesin loader Nipbl, Schwarzer et al. observed that TADs disappear and a fine scale compartmentalization emerges (indicated in red/blue on the left, see Fig.”
Cohesin: its roles and mechanisms. (2009, background): “Scc2 is a large protein containing multiple HEAT repeats within its C-terminal domain (122, 128) and an Scc4binding N-terminal extension whose length varies enormously between species.”
Cohesin relocation from sites of chromosomal loading to places of convergent transcription (2004, background): “Cohesin is initially loaded onto chromosomes at separate places, marked by the Scc2/Scc4 cohesin loading comple”
The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner (2007, neutral): “Cohesins are recruited to chromosomes before DNA replication, a process that requires the SCC2–SCC4 complex and the assembly of preRC (Ciosk et al., 2000; Toyoda et al., 2002; Gillespie and Hirano, 2004; Rollins et al., 2004; Takahashi et al., 2004; Watrin et al., 2006).”