Understanding the role of immune regulation in wound healing.

By Julie E. Park, A. Barbul. American Journal of Surgery, 2004

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Factors affecting wound healing (2010, background): “…in the wound site is associated with impaired wound healing, while others have reported that CD 4+ cells (T-helper cells) have a positive role in wound healing and CD8+ cells (T-suppressor-cytotoxic cells) play an inhibitory role in wound healing (Swift et al., 2001; Park and Barbul, 2004).”
Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “It is likely that Th1- and Th2-cell subsets differentially regulate the wound microenvironment by secreting distinct cytokine profiles (Azouz et al., 2004; Park and Barbul 2004).”
Macrophages are required for adult salamander limb regeneration (2013, background): “Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48–96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast ”
Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis (2020, background): “Overall, malnutrition can compromise the immune response [70], altering cell regeneration and function and making individuals more prone to infection [71].”