The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty

By Michael R. Hunsaker, Jenna S. Rosenberg, R. Kesner. 2008

258 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

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Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “In the final section, we relate our model of generalization to other theoretical positions on this subject.”
Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “For example, lesion and genetic deletion studies have shown that the dentate gyrus is necessary for the discrimination of similar contexts (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008).”
Pattern Separation in the Dentate Gyrus: A Role for the CA3 Backprojection (2010, background): “…recent empirical data regarding selective DG manipulations support the idea that the DG is involved in pattern separation, particularly in tasks that require very similar stimuli to be distinguished (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008; Clelland et al., 2009).”
A Role for Hilar Cells in Pattern Separation in the Dentate Gyrus: A Computational Approach (2009, background): “Consistent with this idea, Hunsaker et al. (2008) found that selective lesions of CA3c, a major source of backprojections to dentate gyrus, were sufficient to disrupt the ability to detect small, local changes within an environment, but did not disrupt the ability to detect large changes in the…”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, background): “In fact, the DG is involved in detecting fine spatial changes in the environment (Hunsaker et al., 2008), probably through adding more detailed information into memory to enhance its resolution.”
Spatial representations of granule cells and mossy cells of the dentate gyrus (2017, background): “Although accumulating evidence strongly supports the role of the DG in pattern separation (Neunuebel and Knierim, 2014; Hunsaker et al., 2008; Nakashiba et al., 2012; Yassa and Stark, 2011; Rolls and Kesner, 2006), the precise computational and circuit mechanisms underlying this role remain under de”
Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus (2012, background): “…selective firing fields (O’Keefe, 1976; Jung and McNaughton, 1993), and altering the activity of the DG disrupts spatial learning tasks (Sutherland et al., 1983; Whishaw, 1987; McNaughton et al., 1989; Xavier et al., 1999; McHugh et al., 2007; Hunsaker and Kesner, 2008; Hunsaker et al., 2008).”
Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells (2017, unknown): “In support of this hypothesis, damage to the dentate gyrus diminishes the animals’ ability to distinguish between similar environmental contexts, supporting its role in pattern separation (Gilbert et al., 2001; McHugh et al., 2007; Hunsaker et al., 2008; Kim and Lee, 2011; Nakashiba et al., 2012).”