Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.

By J. Ricci, C. Muñoz-Pinedo, Patrick Fitzgerald, B. Bailly-maitre, G. Perkins, N. Yadava, I. Scheffler, Mark Ellisman, Douglas R. Green. Cell, 2004

612 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/133cb366c1836dc20c940d1268253b8ed01e66c3

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In Molecular Biology

1. Douglas R. Green
2. R. Youle
3. S. Tait
4. J. Chipuk
5. Guido Kroemer
6. Simone Fulda
7. J. Martinou
8. F. Llambi

Citations in the corpus

• Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario (2006, background): “caspase-dependent cleavage of a subunit of complex I of the respiratory chain and hence can be a byproduct of MOMP rather than causative.(34,35) Otherwise, there is no”
• Cell Death Signaling. (2015, background): “For example, caspase cleavage of the p75 subunit of complex I of the electron transport chain disrupts the mitochondrial transmembrane potential, electron transport, and ATP production during apoptosis (Ricci et al. 2004).”
• Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons (2006, methodology): “Sample preparation and conventional EM were carried out as described before (Ricci et al, 2004).”
• Mitochondria and cell death: outer membrane permeabilization and beyond (2010, background): “Caspase-dependent dissipation of ΔΨ m is mediated, at least in part, through caspase cleavage of NADH–ubiquinone oxidoreductase 75 kDa subunit ( NDUFS1 ), an essential component of respiratory chain complex”
• Apoptosis: controlled demolition at the cellular level (2008, background): “Caspase-mediated proteolysis of the p75 subunit of complex I of the electron transport chain was found to be partially required for the swelling and destructive morphological changes that are suffered by mitochondria during apoptosi”
• Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006, background): “In addition, caspase activity further damages the function of permeabilized mitochondria by affecting the activity of complexes I and II, inevitably leading to the loss of MMP and the generation of reactive oxygen species (Ricci et al., 2004).”