Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

By C. Gross, X. Zhuang, K. Stark, S. Ramboz, R. Oosting, L. Kirby, L. Santarelli, S. Beck, R. Hen. Nature, 2002

901 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/133b3bb5e68fb6aa8b28081832ec65253cab35e4

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Citations in the corpus

Discovering Endophenotypes for Major Depression (2004, background): “…raphe nuclei) during the early postnatal period (but not in the adult) is sufficient to rescue the normal behavioral phenotype of the knockout mice (Gross et al, 2002), suggesting that stimulation of the 5-HT1A receptor during the postnatal period leads to long-lasting changes in the brain…”
Critical period regulation. (2004, background): “Anxiety-like behavior results from appropriate serotonin receptor activation during a critical period of early postnatal life (Gross et al. 2002).”
Is mood chemistry? (2005, background): “org/javawi2/servlet/WIFetch?page=markerDetail&key=10013">5-HT1A receptor produces anxiety-type behaviour in adult mice, but only when the receptor was absent during early postnatal development — its absence in adulthood produces no behavioural effect”
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. (2004, background): “These behaviors are mediated by postsynaptic 5-HT1A receptors in the hippocampus, amygdala, and cortex (94).”
Serotonin and brain function: a tale of two receptors (2017, background): “…and although there are some contradictory findings (File et al., 1996), this effect appears to be mediated by postsynaptic 5-HT1AR signalling (Celada et al., 2013a; Gross et al., 2002; Piszczek et al., 2015; Stefanski et al., 1993; Tauscher et al., 2001; Tu et al., 2014; Zhou et al., 2008, 2014).”
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide (2003, background): “Inducible expression of 5-HT1A receptors in the forebrain of 5-HT1A / mice between postnatal days 5 and 21 was sufficient to restore anxiety-like behavior to normal (Gross et al., 2002), indicating the importance of developmental regulation of 5-HT1A receptors.”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “In this context, it is important to note that anxiety-related behavioral deficits in 5HT-1 A knockout mice are due to the lack of serotonin action during development, and not in the adult (”