A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up.

By C. Widom, K. Dumont, S. Czaja. Archives of General Psychiatry, 2007

1,039 citations recorded by the source corpus.

Subfields: Clinical Psychology, Pediatrics, Perinatology and Child Health, Safety Research

View Paper: https://www.semanticscholar.org/paper/12f9b7c0eb7b92f91999f06fbad04cbf55f12e21

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Citations in the corpus

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014, background): “In addition, retrospective (e.g., Gladstone et al. 1999) and prospective (Widom et al. 2007) studies reveal that early adversities (e.g., physical abuse and neglect) not only increase rates of depression but also accelerate the emergence of depression.”
Neurobiological and psychiatric consequences of child abuse and neglect. (2010, neutral): “For example, Widom, DuMont, and Czaja (2007) performed a prospective longitudinal study of major depression and comorbidity in 676 children with substantiated abuse and neglect experienced before the age of 11 years and a control group of 520 children.”
Violence, crime, and abuse exposure in a national sample of children and youth: an update. (2013, background): “Child maltreatment, peer victimization, and exposure to family and community violence have been shown to be connected to developmental difficulties, problem behavior, and physical and mental health effects extending throughout the life span.(3-6) However, the epidemiology of child victimization rema”
Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. (2012, background): “Epidemiologic studies have shown that childhood maltreatment is a strong risk factor for developing major depression in later life (2), one of the most debilitating diseases worldwide, with up to 30% of all maltreated children fulfilling DSM-IV criteria for major depression in their late 20s (3).”
Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review (2014, neutral): “Nine untranslated first exon variants each possessing their own promoter region have been identified in humans (1A, I, D, J, E, B, F, C and H) and in rats (11, 4-11).”
“The Biological Effects of Childhood Trauma” (2014, neutral): “Childhood traumas, particularly those that are interpersonal, intentional, and chronic are associated with greater rates of PTSD [3], PTSS [4, 5], depression [6] and anxiety [7], antisocial behaviors [8] and greater risk for alcohol and substance use disorders [9-12].”
ELEVATED INFLAMMATION LEVELS IN DEPRESSED ADULTS WITH A HISTORY OF CHILDHOOD MALTREATMENT (2008, neutral): “Initial evidence suggests that depression, inflammation, and cardiovascular disease may share common origins in early-life stress such as childhood maltreatment.(7,16,17) Experimental research also shows that depressed adults with increased early-life stress have greater inflammatory response to an ”
A Meta-Analytic Review of the Effects of Childhood Abuse on Medical Outcomes in Adulthood (2009, background): “For example, findings from a recent prospective study suggested that childhood physical abuse was a risk factor for major depression in adulthood, but childhood sexual abuse was not (13).”