Chromatin organization marks exon-intron structure

By Schraga Schwartz, Eran Meshorer, Gil Ast. Nature Structural &Molecular Biology, 2009

672 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/12ced651940bfbbcaded4489157575abc391bff2

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In Molecular Biology

Citations in the corpus

Complexity of the Alternative Splicing Landscape in Plants[C][W][OPEN] (2013, background): “In addition, the impact of signal-induced changes in cellular milieu, which are known to occur in plants (Seki et al., 2007; Mullen et al., 2012; Chan et al., 2013), on RNA structure and AS is unexplored in plants.”
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs (2012, background): “A number of reports have demonstrated that eukaryotic exonic sequences are enriched in positioned nucleosomes and that some histone modifications show characteristic exonic patterns (Andersson et al. 2009; Hon et al. 2009; Kolasinska-Zwierz et al. 2009; Nahkuri et al. 2009; Schwartz et al. 2009; Spi”
Epigenetics in alternative pre-mRNA splicing (2011, positive): “…along genes and are particularly enriched at intron-exon junctions, thus marking exons (Andersson et al., 2009; Chodavarapu et al., 2010; Dhami et al., 2010; Kolasinska-Zwierz et al., 2009; Nahkuri et al., 2009; Ponts et al., 2008; Schwartz et al., 2009; Spies et al., 2009; Tilgner et al., 2009).”
Widespread intron retention in mammals functionally tunes transcriptomes (2014, background): “For example, H3K36me3 is significantly enriched over exons (Schwartz et al. 2009; Spies et al. 2009; Tilgner et al. 2009), but it is not enriched over retained introns when steady-state expression levels of the corresponding transcripts are controlled for (Fig.”
Dynamic changes in the human methylome during differentiation. (2010, background): “This pattern is likely to be influenced by the higher GC content of exons compared to their surrounding introns, which correlates with nucleosome occupancy and level of the histone modifications (Kolasinska-Zwierz et al. 2009; Schwartz et al. 2009).”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, positive): “Recent genome-wide studies have revealed that nucleosomes are significantly more enriched in exons compared to introns, consistent with other recent findings of enhanced exonic methylation of gene bodies.(93) With the development of next-generation sequencing, DNA methylation patterns over the whole”