Neutrophils in cancer: neutral no more

By S. Coffelt, M. Wellenstein, K. E. Visser. Nature Reviews. Cancer, 2016

1,616 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/122f57b7a2d22835ed88184e7a59deeb1ce5aa1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Weinberg
2. J. Joyce
3. Arthur W. Lambert
4. C. Rosales
5. D. Pattabiraman
6. J. Massagué
7. D. Quail
8. E. Batlle

In Oncology

1. R. Weinberg
2. D. Pattabiraman
3. Arthur W. Lambert
4. J. Massagué
5. J. Joyce
6. E. Batlle
7. D. Quail
8. M. Pittet

Citations in the corpus

• Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “Indeed, tumors can manipulate neutrophils early in their differentiation process, creating a diverse repertoire of functional polarization states (Fridlender et al., 2009; Coffelt et al., 2016).”
• The microenvironmental landscape of brain tumors (2017, background): “The most abundant granulocyte in humans is the neutrophil, which can comprise up to 70% of total leukocytes in the body (Coffelt et al., 2016).”
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “(TANs) Increasing evidence indicates that tumor-associated neutrophils (TANs), a significant component of the TIME, also exhibit phenotypic heterogeneity and functional versatility [144, 145].”
• Transforming Grown Factor-β Signaling in Immunity and Cancer (2019, positive): “80% of MDSCs display a polymorphonuclear phenotype (PMN-MDSCs) similar to that of neutrophils and can be recognized in flow cytometry analysis by the neutrophil surface marker combination CD11b +Ly6G+ (Coffelt et al., 2016; Gabrilovich, 2017).”
• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Neutrophils play important and contradictory roles in cancer development, as reflected by several recent reviews (Sionov et al., 2015; Swierczak et al., 2015; Uribe-Querol and Rosales, 2015; Coffelt et al., 2016; Mishalian et al., 2017).”
• Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species (2019, background): “Tumor-infiltrating neutrophils have been ascribed both anti- and pro-tumor properties, as well as diverse molecular phenotypes (Coffelt et al., 2016; Engblom et al., 2016).”
• Nanomedicine in cancer therapy (2023, background): “113 Neutrophils possess an inherent capacity to traverse the blood-brain barrier, rendering them a promising means of delivering drugs to treat brain tumors.”