Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

By K. Janeway, S. Y. Kim, M. Lodish, V. Nosé, P. Rustin, J. Gaal, P. Dahia, B. Liegl, E. Ball, M. Raygada and 11 more. Proceedings of the National Academy of Sciences of the United States of America, 2010

619 citations recorded by the source corpus.

Subfields: Gastroenterology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/122ab1c0f6893a92feff169150ae34901ce153ee

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Citations in the corpus

• Cancer heterogeneity—a multifaceted view (2013, neutral): “Conversely, gastrointestinal stromal tumours (GISTs) that are induced by either c - KIT or PDGFR - α mutations, present with remarkably similar histology and therapy response [26].”
• Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “The loss of succinate dehydrogenase or fumarate hydratase in tumors leads to altered ratios of α-ketoglutarate to succinate that can affect genome-wide methylation (6, 120, 121).”