Role of duplicate genes in genetic robustness against null mutations

By Zhenglong Gu, Lars M. Steinmetz, X. Gu, C. Scharfe, Ronald W. Davis, Wen-Hsiung Li. Nature, 2003

877 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/121db19f10b39041d7b1295b2f96c483620160cb

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Citations in the corpus

Evidence for dynamically organized modularity in the yeast protein–protein interaction network (2004, background): “A link between the potential scale-free topology of interactome networks and genetic robustnes”
Robustness of Social-Ecological Systems: Implications for Public Policy (2013, background): “Experiments show that deleting a gene in an organism often has little phenotypic effect due to the existence of duplicate genes (subsystem module) or compensation by alternative metabolic pathways (higher level subsystem module performing a similar function) (Gu et al., 2003).”
Why Do Hubs Tend to Be Essential in Protein Networks? (2006, neutral): “It is well known that singleton genes are more likely to be essential than duplicate genes [4,27,28].”
The Functional Significance of Ribosomal (r)DNA Variation: Impacts on the Evolutionary Ecology of Organisms (2005, background): “Although counterintuitive, there may be tighter regulation of rDNA transcription when there are multiple copies in the genome (Gu et al. 2003, 2004).”
Differentiation of the maize subgenomes by genome dominance and both ancient and ongoing gene loss (2011, background): “For example, the loss of highly expressed gene copies in yeast has been shown to be more likely to have a significant impact on fitness than the loss of their less frequently expressed paralogs (35).”
Approaches for extracting practical information from gene co-expression networks in plant biology. (2007, background): “In yeast, it has been reported that there is a higher probability of compensation for duplicate genes (Gu et al. 2003).”
Genetic and epigenetic mechanisms for gene expression and phenotypic variation in plant polyploids. (2007, background): “Gene expression analyses indicate that duplicate genes offer genetic robustness against null mutations in yeast (52) and tend to experience expression divergence during development and to evolve faster between Drosophila species and within yeast species than single-copy genes (51,83).”
An Analysis of Human MicroRNA and Disease Associations (2008, background): “It has been reported that duplicates of protein coding genes are functionally interchangeable[21], suggesting that they may be involved in similar biological processes with similar roles, therefore, may be implicated in the same disease.”
Evolutionary genetics of genome merger and doubling in plants. (2008, background): “However, it is consistent with recent results about the evolution of recently evolved duplicates (41, 73) and with long-term functional compensation (24, 37, 105).”