Tissue-resident macrophages

By L. Davies, S. Jenkins, J. Allen, P. Taylor. Nature Immunology, 2013

1,989 citations recorded by the source corpus.

Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the resolution of inflammation. Recent studies highlight marked heterogeneity in the origins of tissue macrophages that arise from hematopoietic versus self-renewing embryo-derived populations. We discuss the tissue niche-specific factors that dictate cell phenotype, the definition of which will allow new strategies to promote the restoration of tissue homeostasis. Understanding the mechanisms that dictate tissue macrophage heterogeneity should explain why simplified models of macrophage activation do not explain the extent of heterogeneity seen in vivo.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/11e15115c898db61e1e8e6da59f701ff95050733

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Noy
2. J. Pollard
3. Binzhi Qian
4. Jiu-feng Li
5. Luca Cassetta
6. T. Kitamura
7. P. Italiani
8. D. Boraschi

In Neurology

1. Paulina Krzyszczyk
2. Andre F. Palmer
3. Francois Berthiaume
4. J. Pollard
5. R. Schloss
6. P. Italiani
7. Jonathan Kipnis
8. D. Boraschi

Citations in the corpus

• The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes (2018, background): “Monocytederived macrophages are also recruited to the wounded area to further amplify the inflammatory response (Davies et al., 2013).”
• Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “The complexities of different macrophage functions within different tissues are covered in several recent reviews [20][21][22].”
• Macrophages Facilitate Electrical Conduction in the Heart (2017, neutral): “These non-canonical activities highlight macrophages’ functional diversity and emphasize their ability to execute tissue-specific tasks beyond host defense (Davies et al., 2013).”
• Macrophage plasticity, polarization, and function in health and disease (2018, background): “…recent studies provided evidence that most adult tissue-resident macrophages are seeded before birth, derived from the yolk sac during embryonic development, have self-renewal capacity and are maintained independently of monocytes (Davies et al., 2013; Epelman et al., 2014; Hashimoto et al., 2013).”