Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.

By C. Ireson, Donald J L Jones, S. Orr, M. Coughtrie, D. Boocock, Marion L. Williams, P. Farmer, W. Steward, A. Gescher. Cancer Epidemiology, Biomarkers and Prevention, 2002

605 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/11c7367f432b50460f79d04d852ee1815cb1f242

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Citations in the corpus

Curcumin as "Curecumin": from kitchen to clinic. (2008, background): “[155] Ireson CR, Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, et al.”
Bioactivity of dietary polyphenols: The role of metabolites (2020, background): “Glucuronidation of curcumin is catalyzed by UGTs in the intestinal and hepatic microsomes (Ireson et al. 2001, 2002).”
Targets of curcumin (2011, background): “Several pharmacokinetic studies of curcumin showed that curcumin seems to be metabolized through extensive conjugation and reduction in the gastrointestinal tract [252].”
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects (2019, background): “For instance, O-sulfonation of CUR is catalyzed by human phenol sulfotransferase isoenzymes SULT1A1 and SULT1A3 [17,88].”
The Chemistry of Curcumin: From Extraction to Therapeutic Agent (2014, background): “The metabolism of curcumin in rats and humans produces different products [49–53].”
Curcumin, a component of golden spice: from bedside to bench and back. (2014, methodology): “Curcumin was sulfated by human phenol sulfotransferase isoenzymes SULT1A1 and SULT1A3 (Ireson et al., 2002).”
Curcumin: the story so far. (2005, unknown): “This preclinical work was extended using suspensions of isolated human hepatocytes or liver or gut microsomes [23].”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, unknown): “The same investigators extended their work by using suspensions of isolated human hepatocytes or liver or gut microsomes (114).”
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment (2011, background): “The same investigators extended their work by using suspensions of isolated human liver or gut microsomes and the results suggested that the metabolic reduction occurred very rapidly within minutes [45].”
Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa) (2003, unknown): “A difference in curcumin metabolism between humans and rats, a species susceptible to hepatotoxicity with high doses, was demonstrated in a study by Ireson et al. (2002).”