Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.

By U. Senftleben, Y. Cao, G. Xiao, F. Greten, G. Krähn, G. Bonizzi, Y. Chen, Y. Hu, A. Fong, S. Sun and 1 more. Science, 2001

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The complexity of NF-κB signaling in inflammation and cancer (2013, background): “In many cases, p100 is associated with RelB, so that its proteolytic processing induces the formation of a transcriptionally active RelB/p52-complex [38,39].”
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study (2020, background): “Consequently, NIK, together with IKKα, phosphorylates p100, which is further processed to p52, releasing RelB/p52 dimer to translocate into nuclear for target gene activation.(13,15,16) Non-canonical NF-κB pathway is responsible for the development of immune cells in multiple layers.”
NF-kB in development and progression of human cancer (2005, background): “This pathwaymainly activates IKKα, which phosphorylates p100 that is subsequently proteolysed to generate the p52 mature form [17, 59].”
Regulation and Function of IKK and IKK-Related Kinases (2006, background): “Nevertheless, it appears that at least in some pathways of IKK activation, the activating signal is “channeled” to IκB through NIK and IKKα.”