MicroRNA gene expression deregulation in human breast cancer.

By Marilena V. Iorio, M. Ferracin, Chang-Gong Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, M. Campiglio and 10 more. Cancer Research, 2005

4,255 citations recorded by the source corpus.

MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/10bae8b93245299d0e4c4079e76f4d8c10458709

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Citations in the corpus

MicroRNA signatures in human ovarian cancer. (2007, background): “In fact, the miRNA signatures obtained comparing different histotypes of ovarian carcinomas (serous, endometrioid, clear cell, and mixed) with the normal tissue are overlapping in most cases, but they also reveal a number of miRNAs that seem to be ‘‘histotype specific’’: the endometrioid tumors, for”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, methodology): “This technology, and other techniques including quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR), can identify distinct miRNA expression patterns that can characterize specific tissue and disease states, distinguishing between subtypes of normal and malignant tissues [278, 336,”
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene (2008, background): “Recent reports have identified miR-21 as the only miRNA that is overexpressed in nine types of solid tumors (lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pancreas) (Chan et al., 2005; Iorio et al., 2005; Diederichs and Haber, 2006; Roldo et al., 2006; Volinia et al., 2”
MicroRNA-cancer connection: the beginning of a new tale. (2006, background): “Reduced expression in breast cancers (11)”
A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes (2006, background): “Consistent with a role in controlling these processes, numerous studies have now documented widespread dysregulation of these molecules in diverse cancers (Michael et al., 2003; Calin et al., 2004a; Iorio et al., 2005; Lu et al., 2005; He et al., 2005a; Volinia et al., 2006).”
Breast cancer intrinsic subtype classification, clinical use and future trends. (2015, background): “MiR-125b, miR-145, miR-21 and miR155 were reported to be the most dysregulated miRNAs in their study, and some of these malfunctional miRNAs were correlated with specific clinical features of breast tumors including the expression of hormone receptors, tumor stage, vascular invasion and proliferatio”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “miR-9, miR10b, miR-29a, miR-96, miR-146a, miR-181, miR-373, miR-375, miR-520c, miR589 BC cell lines [162-165, 167, 198, 199]”
MicroRNAs in development and disease. (2011, background): “Early studies showing the differential expression pattern of miRNAs in breast cancer tissue revealed that some of the more significantly upregulated included miR-21 and miR-155, and those downregulated included miR-125b and miR-145 (267).”
let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, result): “let-7 expression in normal adjacent breast tissue was 35% higher than in 1 cancer cells depleted of BT-IC, consistent with a prior report that breast cancers express less let-7 than normal breast tissue (Iorio et al., 2005).”
A SNP in a let-7 microRNA complementary site in the KRAS 3′UTR Increases Non-Small Cell Lung Cancer Risk (2008, background): “For example, SNPs in miRNAs important in cancer have been identified; mir-125a , shown to be altered in breast cancer (5, 6), has a variant allele at a SNP in the mature miRNA sequence that decreases expression (7).”
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin (2008, background): “Recent findings have confirmed a critical role of miRNA as powerful diagnostic and prognostic indicators of human breast cancer (15, 16, 37, 38, 44), resulting in the develop-”