HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

By J. Martin-Serrano, Trinity M Zang, P. Bieniasz. Nature Medicine, 2001

753 citations recorded by the source corpus.

Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health, Virology

View Paper: https://www.semanticscholar.org/paper/10b2e5dd538f9627bb8aa419f1e5b048a19b5373

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In Public Health, Environmental and Occupational Health

1. C. Seeger
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2. W. Mason

Citations in the corpus

• Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein (2012, background): “The dramatic relocalization of TSG101 from endosomes to plasma membrane by ARRDC1 is reminiscent of TSG101 recruitment by the HIV Gag protein during HIV budding (21, 22, 29).”
• Lassa Virus Z Protein Is a Matrix Protein Sufficient for the Release of Virus-Like Particles (2003, background): “Late domains were originally identified in the Gag proteins of a number of retroviruses and in the matrix proteins of rhabdo- and filoviruses and interact with cellular target proteins to promote virus particle release by membrane fission (11, 12, 15, 17, 18, 26, 27, 37, 38).”
• PPPYEPTAP Motif Is the Late Domain of Human T-Cell Leukemia Virus Type 1 Gag and Mediates Its Functional Interaction with Cellular Proteins Nedd4 and Tsg101 (2003, methodology): “Tsg101 also binds PTAP motif in VP40 Ebola virus (33, 60); both proteins colocalize at the plasma membrane (35), where Tsg101 directed the budding of Ebola virus particles to occur in membrane raft microdomains (33).”
• The ESCRT pathway. (2011, background): “Similar to HIV-1, other viruses contain L-domain proteins that interact directly with the ESCRT 82 Developmental Cell 21, July 19, 2011 ª2011 Elsevier Inc. machinery (Carpp et al., 2011; Martin-Serrano et al., 2001; Urata et al., 2007; Wirblich et al., 2006).”
• HIV-1 assembly, budding, and maturation. (2012, background): “The primary “PTAP” late domain binds the TSG101 subunit of the heterotetrameric ESCRT-I complex (Garrus et al. 2001; Martin-Serrano et al. 2001; VerPlank et al. 2001; Demirov et al. 2002; Morita and Sundquist 2004; Bieniasz 2009).”
• Tetherin inhibits HIV-1 release by directly tethering virions to cells (2009, neutral): “…Assays To measure tetherin activity, 293T cells in 24 well plates were transfected using polyethylenimine (PolySciences) with 500 ng of HIV-1(WT), HIV-1(delVpu) proviral plasmids (Neil et al., 2006), or 400 ng of a plasmid expressing myctagged Ebola virus VP40 (Martin-Serrano et al., 2001).”
• The protein network of HIV budding. (2003, background): “…et al., 1997), [3] (Bache et al., 2003a; Lu et al., 2003; Pornillos et al., 2003), [4] (Martin-Serrano et al., 2003), [5] (Demirov et al., 2002a; Garrus et al., 2001; Martin-Serrano et al., 2001; form a stable complex in mammalian cells (Kamura et and CHMP2B did not show any positive interactions.”