Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study

By R. Schmidt, H. Schmidt, J. Curb, K. Masaki, L. White, Lenore J. Launer. Annals of Neurology, 2002

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Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “The involvement of mid-life, increased CRP levels in dementia has been examined in the Honolulu Asia Aging Study (Schmidt et al., 2002).”
Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. (2004, background): “6 In addition, our observations on CRP are in accord with the recent finding of elevated CRP levels 25 years before the clinical onset of dementia, AD, and vascular dementia.(7) To our knowledge, blood levels of CAMs in relation to dementia have not been studied before, but neuropathological finding”
Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels (2019, background): “In addition to depression and CVD, inflammation is associated with other physical and psychiatric disorders including diabetes mellitus (Pradhan et al., 2001), schizophrenia (Miller et al., 2011; Khandaker et al., 2015) and dementias (Schmidt et al., 2002).”
Inflammatory markers in population studies of aging (2010, neutral): “…AD and vascular dementia have been observed in the Rotterdam Study (Engelhart, Geerlings et al. 2004) and the Honolulu-Asia Aging Study (Schmidt, Schmidt et al. 2002) and the levels of these markers were found to be elevated before the onset of clinical symptoms indicating possible relevance of…”