The Design of Scaffolds for Use in Tissue Engineering. Part II. Rapid Prototyping Techniques

By Shoufeng Yang, K. Leong, Z. Du, C. K. Chua. Tissue engineering, 2002

748 citations recorded by the source corpus.

Tissue engineering (TE) is an important emerging area in biomedical engineering for creating biological alternatives for harvested tissues, implants, and prostheses. In TE, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three-dimension (3D). However, existing 3D scaffolds for TE proved less than ideal for actual applications because they lack mechanical strength, interconnected channels, and controlled porosity or pores distribution. In this paper, the authors review the application and advancement of rapid prototyping (RP) techniques in the design and creation of synthetic scaffolds for use in TE. We also review the advantages and benefits, and limitations and shortcomings of current RP techniques as well as the future direction of RP development in TE scaffold fabrication.

Subfields: Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/10837a579dc9c3c8ee6226c975b68c10f0eb6b11

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Qiu Li Loh
2. Cleo Choong
3. P. Ma
4. M. Chandrasekaran
5. Aldo R. Boccaccini
6. K. Leong
7. B. Chan
8. W. Y. Yeong

In Surgery

1. P. Ma
2. Aldo R. Boccaccini
3. L. Gerhardt
4. Qiu Li Loh
5. Cleo Choong
6. B. Chan
7. K. Leong
8. Jae Nam

Citations in the corpus

• Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering (2010, positive): “Similarly, focused photoablation achieved using pulsed lasers in PEGylated fibrinogen hydrogels successfully created microchannels of controlled size that were shown to drive the directional growth of neurites.(97) Creation of microchannels to control both nutrient transport and cellular alignment, ”
• Bio-CAD modeling and its applications in computer-aided tissue engineering (2005, background): “In addition, thus designed scaffolds often can only be fabricated through advanced manufacturing techniques, such as solid freeform fabrication (SFF) to manufacture complex structural architectures [8, 37 ].”
• Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. (2005, background): “nologies for the manufacturing of scaffolds for tissue engineering.(2) The materials used in RP processes are polymers,”
• Scaffolding in tissue engineering: general approaches and tissue-specific considerations (2008, methodology): “Example techniques include solvent casting and particulate leaching, gas foaming, freezedrying and phase separation [124].”
• Rapid prototyping in tissue engineering: challenges and potential. (2004, background): “As a result, RP is seen to be a viable alternative for achieving extensive and detailed control over scaffold architecture [18, 19 ].”
• Biomimetic materials for tissue engineering. (2008, methodology): “solid freeform fabrication (SFF) or rapid prototyping, that have been widely used in modern manufacture industry, are adopted by the field of tissue engineering [3,95-98].”
• Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size (2013, positive): “22 23–26 Alternative approaches to prefabrication of scaffolds prior to cell seeding include cell encapsulation, and the development of tunable scaffolds that have the potential for further modification postimplantation.”