Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering
By N. Annabi, J. Nichol, Xiamei Zhong, Chengdong Ji, Sandeep T. Koshy, Ali Khademhosseini, Fariba Dehghani. Tissue engineering. Part B, Reviews, 2010
1,197 citations recorded by the source corpus.
Tissue engineering holds great promise for regeneration and repair of diseased tissues, making the development of tissue engineering scaffolds a topic of great interest in biomedical research. Because of their biocompatibility and similarities to native extracellular matrix, hydrogels have emerged as leading candidates for engineered tissue scaffolds. However, precise control of hydrogel properties, such as porosity, remains a challenge. Traditional techniques for creating bulk porosity in polymers have demonstrated success in hydrogels for tissue engineering; however, often the conditions are incompatible with direct cell encapsulation. Emerging technologies have demonstrated the ability to control porosity and the microarchitectural features in hydrogels, creating engineered tissues with structure and function similar to native tissues. In this review, we explore the various technologies for controlling the porosity and microarchitecture within hydrogels, and demonstrate successful applications of combining these techniques.
Subfields: Biomaterials, Biomedical Engineering, Surgery
View Paper: https://www.semanticscholar.org/paper/709c99764dc2dee5a870ca52041878cfeba3c4e5
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In Biomaterials
In Biomedical Engineering
Citations in the corpus
- Electrospun Scaffolds for Tissue Engineering of Vascular Grafts (2013, neutral): “In this method, salt particles or some other type of sacrificial polymers are initially added and dissolved or leached out after the creation of a polymer network [81].”
- Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach. (2015, background): “important role in directing cellular behavior, as the size and distribution of pores within scaffolds dictate the cellular infiltration and distribution of cells throughout the network.(25) Gel hydrogels showed a uniform and highly interconnected network, similar to previously published literature.”
- Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals (2019, methodology): “For instance, leaching out the template materials from the structure network is a common method for making porous materials [144].”