Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells.
By R. Castriconi, C. Cantoni, M. Della Chiesa, M. Vitale, E. Marcenaro, R. Conte, R. Biassoni, C. Bottino, L. Moretta, A. Moretta. Proceedings of the National Academy of Sciences of the United States of America, 2003
732 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/0f7b90e6cf87c9982f0b73c8e3dae8199e3c17f9
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Citations in the corpus
- Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “TGF-β also inhibits the cytolytic activity of natural killer (NK) cells expressing the activating receptor NKG2D, further resulting in a poor antitumor response [79, 80].”
- Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells (2012, background): “Donor KIR-mismatched NK cells can suppress recipient derived lymphocytes, reducing the risk of rejection, and react against recipient dendritic cells [7], thereby reducing the allostimulous for GvHD [8].”
- Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β11 (2009, background): “Moreover, TGF- 1 produced by tumor cells or Tregs can exert its inhibitory effects in soluble or membrane-bound manner (19, 20).”
- NK cells and cancer immunosurveillance (2008, background): “Down-regulation of NKG2D is also mediated by TGF-b, a potent immunosuppressive cytokine (Castriconi et al., 2003; Friese et al., 2004; Lee et al., 2004), and L-kynurenine, a tryptophane catabolite generated by indoleamine 2,3-dioxygenase (IDO) (Della Chiesa et al.”
- The polarization of immune cells in the tumour environment by TGFβ (2010, background): “It has been shown that exogenously administered TGFβ inhibits NKp30 and NKG2D expression, leading to decreased ability of NK cells to kill target cell”